Mercy Corps Pakistan is conducting a cost-effective analysis of different active TB case-finding models, including the latest technology, for optimizing resource allocation in countries burdened by high TB prevalence like Pakistan. This study will evaluate the cost-effectiveness of diverse implementing strategies for screening, sample collection, and diagnostic tools to identify TB patients during Active Case Finding (ACF). A cluster randomized cross-over trial (CRXO) will be employed with three arms comparing novel ACF strategies using varying screening tools and targeting high-risk communities, household, and neighborhood contacts using mobile screening units.

CGPH will take the lead on scientific aspects, applying program science approach to the study, conducting evaluations at baseline, midline, and end line, monitoring interventions, and performing research studies, including qualitative assessments to gauge the feasibility of new methods.

CGPH will also assist in executing the dissemination plan, which includes organizing seminars, advocacy efforts, and publishing manuscripts and abstracts. An extensive report or white paper will be created to inform all relevant stakeholders about the new tools being tested and the pragmatic trial. This report will be supported by original research and publications.

Partner: Mercy Corps Pakistan

CGPH is leading the analysis of intervention outcome of Active Case Finding (ACF) Screening Program for targeting strategies. It is a pragmatic stepped wedge cluster randomized trial that will evaluate whether a targeted approach towards ACF, supported by artificial-intelligence software (MATCH-AI), can increase yields of TB cases detected. The study is being conducted on a national scale in Pakistan and is embedded within the routine operations of the implementing partners of the National TB Program. The study will provide empirical evidence for the potential benefit of targeting of ACF interventions in a real-world setting, within a high-burden TB country.

Partner: Mercy Corps Pakistan

A capacity building initiative has been designed to introduce the program staff (MC and SRs) to the concept of how routine program data could be utilized to learn about the program, identify areas for research and improvement, and set goals. While the focus should be on developing early and mid-career researchers, consideration will be given to all stages of career pathway skills for future career development for all selected staff.

Partner: Mercy Corps Pakistan & SR's

CGPH-Pakistan is leading the analysis of intervention outcome of Active Case Finding (ACF) Screening Program for targeting strategies. It is a pragmatic stepped wedge cluster randomized trial that will evaluate whether a targeted approach towards ACF, supported by artificial-intelligence software (MATCH-AI), can increase yields of TB cases detected. The study is being conducted on a national scale in Pakistan and is embedded within the routine operations of the implementing partners of the National TB Program. The study will provide empirical evidence for the potential benefit of targeting of ACF interventions in a real-world setting, within a high-burden TB country.

Partner: Mercy Corps Pakistan